Important: VAERS reports alone cannot determine if a vaccine caused an adverse event. Reports may contain incomplete, inaccurate, or unverified information. Correlation does not equal causation.
Shingles vaccines are given to older adults to prevent herpes zoster (shingles). The older Zostavax (live vaccine) has been largely replaced by Shingrix (recombinant). Shingrix is known for causing more noticeable — but generally harmless — side effects.
The following symptoms are most frequently reported after vaccination:
Shingrix is known for more pronounced side effects than most vaccines — this is partly because it contains a strong adjuvant (AS01B) designed to boost immune response in older adults. The side effects are a sign the immune system is responding.
Very common with Shingrix (expected in most recipients):
These side effects are notably more common than with most vaccines but typically resolve within 2-3 days. The second dose tends to cause more side effects than the first.
The high VAERS report count for shingles vaccines reflects both the strong reactogenicity of Shingrix and the older age of recipients. Older adults may be more likely to seek medical attention for side effects, and healthcare providers may be more likely to report events in elderly patients.