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Data source: VAERS (Vaccine Adverse Event Reporting System)

Data through 2026 · Updated quarterly

Built by TheDataProject.ai · © 2026 VaccineWatch

Important: VAERS accepts reports of adverse events following vaccination. For any given report, there is no certainty that the reported event was caused by the vaccine. Reports may contain information that is incomplete, inaccurate, coincidental, or unverifiable. Most reports to VAERS are voluntary, which means they are subject to biases. This data cannot be used to determine if vaccines cause or contribute to adverse events.

⚠️

Important: VAERS reports alone cannot determine if a vaccine caused an adverse event. Reports may contain incomplete, inaccurate, or unverified information. Correlation does not equal causation.

  1. Home
  2. Vaccines
  3. Smallpox (Acam2000)

Smallpox (Acam2000)

SMALL8,768 total reports
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Manufacturers:

Emergent BioSolutionsPfizer / WyethUnknown Manufacturer

Smallpox (Acam2000) has 8,768 reports in VAERS spanning from 1990 to 2026. Of these reports, 50 mentioned death, 1,788 involved hospitalization, and 4,670 required emergency department visits. This vaccine is manufactured by: Emergent BioSolutions, Pfizer / Wyeth, Unknown Manufacturer. This vaccine accounts for 0.4% of all 1,983,260 reports in the VAERS database.

8,768
Total Reports
50
Deaths
1,788
Hospitalizations
4,670
ER Visits
140
Disabilities

About Smallpox (Acam2000)

Smallpox (Acam2000) has 8,768 reports in VAERS spanning from 1990 to 2026.

Of these reports, 50 mentioned death, 1,788 involved hospitalization, and 4,670 required emergency department visits.

This vaccine is manufactured by: Emergent BioSolutions, Pfizer / Wyeth, Unknown Manufacturer.

This vaccine accounts for 0.4% of all 1,983,260 reports in the VAERS database.

Reporting Rate

This vaccine averages 292 reports per year over 30 years of reporting (1990–2025).

Understanding These Numbers

•Reports don't prove causation. They represent temporal associations where someone experienced an event after vaccination.
•Background rates matter. Many conditions occur naturally and may coincidentally happen after vaccination.
•Reporting varies by vaccine. Newer vaccines or those in the news may have higher reporting rates due to increased awareness.

Most Reported Symptoms

1. Chest pain(all)
1,437
2. Pyrexia(all)
1,276
3. Headache(all)
971
4. Rash(all)
887
5. Pain(all)
859
6. Dyspnoea(all)
818
7. Erythema(all)
797
8. Pruritus(all)
768
9. Injection site erythema(all)
705
10. Lymphadenopathy(all)
675

Top Reporting States

1. Virginia614
2. California559
3. Texas474
4. North Carolina339
5. Washington260
6. New York244
7. Florida238
8. Maryland227

Reports by Year

202518
202430
20237
202214
202126
202034
2019123
2018153
2017131
201694

Explore Further

⚖️ Compare SMALL with OthersRead Analysis Articles

Related Analysis

The Denominator ProblemUnderstanding Reporting BiasWhen Do Side Effects Start?Death Reports Deep DiveSerious Outcomes AnalysisMost Common Symptoms

Data Source

This data comes from the Vaccine Adverse Event Reporting System (VAERS), jointly managed by CDC and FDA.